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pentobarbital will decrease the extent or result of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Avoid Except the coadministration outweighs the attainable threat of ponatinib underexpos